صفحه محصول - پاورپوینت با عنوان کم کاری تیرویید نوزادان

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کم کاری تیرویید نوزادان Causes of Congenital Hypothyroidism Developmental defects 1 every 4000 newborns; In Iran >1/1000 Complete absence of thyroid tissue Failure of thyroid to descend properly during embryologic development Route of descent (foramen caecum at the junction of anterior two thirds and posterior third of tongue to normal site or below) Biosynthetic defects in the thyroid Pituitary or hypothalamic failure Family with mutation in gene coding TSH β subunit Thyroid disorders and their approximate prevalence in the neonatal period Thyroid dysgenesis >1:1000-1:4000 Agenesis Hypogenesis Ectopia Thyroid dyshormonogenesis 1:40,000 Thyroid-stimulating hormone unresponsiveness Iodide trapping defect Organification defect Defect in thyroglobulin Iodotryrosine deiodinase deficiency Transient hypothyroidism 1:40,000 Drug induced Maternal antibody induced Idiopatic Hypothalamic-pituitary hypothyroidism 1:100,000 Hypothalamic-pituitary anomaly Panhypopituitarism Isolated thyroid-stimulating hormone deficiency Thyroid hormone resistance Differential diagnosis of transient congenital hypothyroidism Primary hypothyroidism Prenatal or postnatal iodine deficiency or excess Maternal antithyroid medication Maternal TSH receptor blocking antibodies Secondary or tertiary hypothyroidism Prenatal exposure to maternal hyperthyroidism Prematurity (particularly <27 weeks’ gestation) Drugs Steroids Dopamine Miscellaneous Isolated TSH elevation Low T4 with normal TSH Prematurity Undernutrition Low-T3 syndrome